Non-dipper status and left ventricular hypertrophy as predictors of incident chronic kidney disease

Area of Science:

• Nephrology
• Cardiology
• Hypertension Research

Background:

• Hypertension is a major risk factor for chronic kidney disease (CKD).
• Non-dipper blood pressure patterns and left ventricular hypertrophy (LVH) are common in hypertensive patients.
• The association between non-dipper status, LVH, and incident CKD in non-diabetic hypertensive individuals requires further investigation.

Purpose of the Study:

• To investigate the association between non-dipper status, LVH, and the development of CKD.
• To identify predictors of incident CKD in non-diabetic hypertensive patients.

Main Methods:

• Prospective study of 102 non-diabetic hypertensive patients with eGFR ≥ 60 mL/min/1.73 m(2).
• Ambulatory blood pressure monitoring and echocardiography were performed.
• Patients were followed for an average of 51 months for CKD development, assessed by serum creatinine and urine albumin/creatinine ratio.

Main Results:

• CKD developed in 11 patients during follow-up.
• Non-dipper status (19.0% vs 5.0%) and LVH were significantly more prevalent in patients who developed CKD.
• Incident CKD was associated with higher urine albumin/creatinine ratio, non-dipper status, LVH, and lower HDL-cholesterol.

Conclusions:

• Non-dipper status and LVH are independent predictors of incident CKD in non-diabetic hypertensive patients.
• These findings suggest that non-dipper status and LVH are potential therapeutic targets for CKD prevention in this population.