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Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...

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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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Published on: October 14, 2016

Soft tissue sarcomas in children.

Gauri Kapoor1, Kunal Das

  • 1Department of Pediatric Hematology and Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, Delhi 110085, India. gauri_kapoor2000@yahoo.com

Indian Journal of Pediatrics
|September 22, 2011
PubMed
Summary
This summary is machine-generated.

Pediatric soft tissue sarcomas (STS) are rare childhood cancers. Rhabdomyosarcomas (RMS) and non-rhabdomyosarcomas (NRSTS) have different age groups and treatment approaches, with chemotherapy for RMS and surgery for NRSTS.

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Area of Science:

  • Pediatric Oncology
  • Surgical Oncology
  • Medical Oncology

Background:

  • Pediatric soft tissue sarcomas (STS) represent approximately 7% of childhood cancers.
  • Rhabdomyosarcomas (RMS) account for half of pediatric STS, with non-rhabdomyosarcoma STS (NRSTS) comprising the remainder.
  • RMS typically affect younger children (<6 years), while NRSTS are more common in adolescents and young adults.

Purpose of the Study:

  • To review the characteristics, treatment strategies, and outcomes of pediatric soft tissue sarcomas.
  • To differentiate the management approaches for RMS and NRSTS.
  • To highlight challenges in treating NRSTS and the generally poor prognosis for metastatic or recurrent STS.

Main Methods:

  • Review of existing literature on pediatric STS.
  • Analysis of treatment modalities including chemotherapy, surgery, and radiotherapy.
  • Discussion of staging, risk stratification, and multidisciplinary care.

Main Results:

  • Chemotherapy is the primary treatment for RMS, with local control achieved via surgery and/or radiotherapy.
  • Surgery is the mainstay for NRSTS, which are often chemotherapy-resistant.
  • Successful treatment of NRSTS relies on achieving wide local excision with negative margins.

Conclusions:

  • Pediatric STS management requires a tailored, multidisciplinary approach based on tumor type, stage, and histology.
  • NRSTS present significant treatment challenges due to their chemotherapy resistance.
  • The prognosis for metastatic and recurrent pediatric STS remains poor.