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Related Experiment Video

Updated: May 29, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

Published on: March 11, 2014

[HPV-associated squamous cell carcinogenesis].

G Assmann¹, K Sotlar

¹Pathologisches Institut, Ludwig-Maximilians-Universität München, Thalkirchner Straße 36, 80337, München, Deutschland.

|September 22, 2011

Summary

This summary is machine-generated.

High-risk human papillomavirus (HPV) infections cause about 7-8% of human cancers, particularly cervical, anogenital, and oropharyngeal cancers. Persistent HPV infection, driven by E6/E7 oncogenes, is a key risk factor for developing these HPV-associated cancers.

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Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

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Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples

Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples

Published on: July 29, 2017

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Last Updated: May 29, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

Published on: March 11, 2014

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

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Published on: June 14, 2019

Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples

Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples

Published on: July 29, 2017

Area of Science:

Oncology
Virology
Molecular Biology

Context:

High-risk human papillomavirus (HR-HPV) is linked to approximately 7-8% of human cancers.
Cancers associated with HR-HPV include cervical, anogenital, and oropharyngeal squamous cell carcinomas.
Harald zur Hausen's Nobel Prize-winning research established the causal link between HPV and cervical cancer.

Purpose:

To review the role of persistent high-risk human papillomavirus (HR-HPV) infections in cancer development.
To discuss the molecular mechanisms underlying HPV-associated oncogenesis.
To highlight the significance of prophylactic HPV vaccines.

Summary:

Persistent HR-HPV infection is the primary risk factor for HPV-associated neoplasias.
The viral E6 and E7 oncogenes disrupt cell cycle control, leading to uncontrolled proliferation and apoptosis resistance.
Genomic instability and mutations may drive malignant transformation in infected cells.

Impact:

Understanding HPV's role in cancer is crucial for prevention and treatment strategies.
Prophylactic vaccines targeting HPV-16 and HPV-18 offer significant protection against infection.
Continued research into HPV oncogenesis can lead to improved cancer therapies.