Related Experiment Video
Updated: May 29, 2026
07:35
Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
Multicystic dysplastic kidney: four-year evaluation.
Berna Aytaç1, Ibrahim Sehıtoğlu, Hakan Vuruskan
1Department of Pathology Uludağ University, Faculty of Medicine, Bursa, Turkey. berbun@gmail.com
Turk Patoloji Dergisi
|September 22, 2011
Summary
Multicystic dysplastic kidney (MCDK) in children can present with other urinary tract anomalies. Surgical removal of MCDK is a management option due to potential risks, though a conservative approach is also considered.
Area of Science:
- Pediatric Nephrology
- Urology
- Developmental Biology
Background:
- Multicystic dysplastic kidney (MCDK) is a common congenital kidney abnormality in children.
- MCDK can be associated with other urinary tract anomalies, including vesicoureteral reflux and ureteropelvic junction obstruction.
Purpose of the Study:
- To review the pathogenesis, diagnosis, associated anomalies, and management outcomes of MCDK in pediatric patients.
- To evaluate the results of surgical management (nephrectomy) for unilateral MCDK.
Main Methods:
- Retrospective review of 20 children with unilateral MCDK treated between January 2005 and December 2009.
- Analysis of patient characteristics, pathology findings, associated urinary tract anomalies, and management outcomes.
- All patients underwent nephrectomy for MCDK.
Main Results:
- Associated urinary tract anomalies identified included vesicoureteral reflux (15%), ureteropelvic junction obstruction (15%), and contralateral duplex system (5%).
- All children maintained normal blood pressure, serum urea, creatinine, and urinalysis during a mean follow-up of 35 months.
- Nephrectomy was performed in all cases.
Conclusions:
- While a conservative approach for MCDK is sometimes advocated, surgical removal is a viable option.
- Considerations for surgical management include risks of hypertension, mass effect, potential malignancy, and costs associated with monitoring.
Related Concept Videos
01:25Chronic Kidney Disease I: Introduction
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
01:29Acute Kidney Injury III: Clinical Manifestations
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
01:28Imaging Studies I: Kidney, Ureter, and Bladder Studies
Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
01:28Chronic Kidney Disease III: Interprofessional Care
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
01:18Chronic Kidney Disease IV: Nursing Management
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...
01:24Chronic Kidney Disease II: Clinical Manifestations
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...