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Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
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Multicystic dysplastic kidney: four-year evaluation

Berna Aytaç1, Ibrahim Sehıtoğlu, Hakan Vuruskan

  • 1Department of Pathology Uludağ University, Faculty of Medicine, Bursa, Turkey. berbun@gmail.com

Turk Patoloji Dergisi
|September 22, 2011
PubMed

Insights

Multicystic dysplastic kidney (MCDK) in children can present with other urinary tract anomalies. Surgical removal of MCDK is a management option due to potential risks, though a conservative approach is also considered.

Area of Science:

  • Pediatric Nephrology
  • Urology
  • Developmental Biology

Background:

  • Multicystic dysplastic kidney (MCDK) is a common congenital kidney abnormality in children.
  • MCDK can be associated with other urinary tract anomalies, including vesicoureteral reflux and ureteropelvic junction obstruction.

Purpose of the Study:

  • To review the pathogenesis, diagnosis, associated anomalies, and management outcomes of MCDK in pediatric patients.
  • To evaluate the results of surgical management (nephrectomy) for unilateral MCDK.

Main Methods:

  • Retrospective review of 20 children with unilateral MCDK treated between January 2005 and December 2009.
  • Analysis of patient characteristics, pathology findings, associated urinary tract anomalies, and management outcomes.
  • All patients underwent nephrectomy for MCDK.

Main Results:

  • Associated urinary tract anomalies identified included vesicoureteral reflux (15%), ureteropelvic junction obstruction (15%), and contralateral duplex system (5%).
  • All children maintained normal blood pressure, serum urea, creatinine, and urinalysis during a mean follow-up of 35 months.
  • Nephrectomy was performed in all cases.

Conclusions:

  • While a conservative approach for MCDK is sometimes advocated, surgical removal is a viable option.
  • Considerations for surgical management include risks of hypertension, mass effect, potential malignancy, and costs associated with monitoring.
Abstract

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