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Related Concept Videos

Lateralization01:28

Lateralization

Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
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Visual agnosia is a condition characterized by the inability to recognize visually presented objects despite having normal vision. For instance, a person with visual agnosia can describe the shape and color of an object but cannot identify or name it. This impairment does not affect their visual field, acuity, color vision, brightness discrimination, language, or memory. An example of this condition in a social setting is someone at a dinner party asking for "that silver thing with a round end"...
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Updated: May 29, 2026

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

How number processing survives left occipito-temporal damage.

M Cappelletti1, A P Leff, C J Price

  • 1Institute of Cognitive Neuroscience, University College London, London, UK. m.cappelletti@ucl.ac.uk

Neurocase
|September 23, 2011
PubMed
Summary
This summary is machine-generated.

Damage to the left ventral occipito-temporal cortex (LvOT) impairs efficient number processing but not accuracy. Alternative brain regions, including the right hemisphere and frontal lobes, can support accurate number decisions.

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • The left ventral occipito-temporal cortex (LvOT) is typically involved in number processing.
  • Patient JL with LvOT damage showed impaired word recognition but accurate, albeit slow, number processing.

Observation:

  • fMRI data compared JL's brain activity during number tasks to healthy controls and patients with frontal lobe damage.
  • JL did not activate the typical LvOT region for semantic over perceptual number decisions.
  • JL showed increased activation in the left posterior middle temporal region, right occipito-temporal cortex, right caudate, and bilateral frontal regions.

Findings:

  • LvOT activation is crucial for efficient, but not essential for accurate, number processing.
  • Perceptual number decisions can be supported by right occipital, right caudate, and bilateral frontal areas.
  • Semantic number decisions can be supported by increased left posterior middle temporal activation linked to hand actions.

Implications:

  • This study reveals neural plasticity and alternative pathways for number processing after brain injury.
  • Understanding these compensatory mechanisms can inform rehabilitation strategies for individuals with number processing deficits.