Messengers, motors and mysteries: sorting of eukaryotic mRNAs by cytoskeletal transport
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Updated: May 29, 2026

Characterizing the Composition of Molecular Motors on Moving Axonal Cargo Using "Cargo Mapping" Analysis
Published on: October 30, 2014
1Cell Biology Division, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. sbullock@mrc-lmb.cam.ac.uk
Abstract:
It has become increasingly apparent in recent years that the subcellular localization of specific mRNAs is a prevalent method for spatially controlling gene expression. In most cases, targeting of mRNAs is mediated by transport along cytoskeletal filaments by molecular motors. However, the means by which specific messages are recognized and linked to the motors are poorly understood. Here, I will provide an overview of recent progress in elucidating the molecular mechanisms and principles of mRNA transport, including several studies highlighting the co-operation of different motors during the localization process. Important outstanding questions will also be highlighted.
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