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Updated: May 29, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Migraine attacks the Basal Ganglia.

Nasim Maleki¹, Lino Becerra, Lauren Nutile

¹Department of Radiology, Children’s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

|September 23, 2011

Summary

Migraine progression involves changes in the basal ganglia, a brain region crucial for pain processing. This study reveals differences in brain structure and function between patients with progressing versus non-progressing episodic migraine.

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Area of Science:

Neuroscience
Neurology
Medical Imaging

Background:

Episodic migraine attacks can increase in frequency, duration, and intensity over time.
The progression from episodic to chronic migraine is poorly understood.
This study investigates brain differences in migraine patients with progressing versus non-progressing disease.

Purpose of the Study:

To compare functional responses, connectivity, and brain morphology in episodic migraine patients.
To identify neurobiological differences associated with migraine progression.

Main Methods:

High-field human brain imaging techniques were employed.
Functional responses, functional connectivity, and brain morphology were analyzed.
Patients were grouped into low-frequency (LF) and high-frequency (HF) episodic migraine based on progression.

Main Results:

High-frequency (HF) episodic migraine patients showed lower pain responses in the caudate, putamen, and pallidum compared to low-frequency (LF) patients.
HF patients exhibited larger gray matter volume in the caudate nuclei bilaterally.
Functional connectivity analyses revealed further distinctions between LF and HF groups during pain response.

Conclusions:

Findings suggest a significant role for the basal ganglia in the pathophysiology of episodic migraine.
The basal ganglia's involvement in pain processing may be altered in migraine progression.
These results provide insights into the neurobiological mechanisms underlying migraine chronification.