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Our understanding of the Pasteurellaceae
1Department of Veterinary Microbiology and Immunology, University of California, Davis 95616.
Summary
Members of the Pasteurellaceae family are often harmless commensals but can cause disease in stressed animals. Pathogenesis involves toxins, and acquired resistance is antibody-dependent, potentially achievable through biotechnology.
Area of Science:
- Veterinary Microbiology
- Bacterial Pathogenesis
- Immunology
Background:
- Pasteurellaceae members are typically commensal parasites on vertebrate mucous membranes.
- Certain species like Pasteurella multocida and Actinobacillus pleuropneumoniae are significant pathogens.
- Pathogenic potential is often triggered by host immunodeficiency and stress.
Purpose of the Study:
- To review the pathogenesis and disease patterns associated with Pasteurellaceae infections.
- To discuss the role of toxins and inflammatory responses in disease.
- To explore strategies for achieving acquired resistance against Pasteurellaceae.
Main Methods:
- Review of existing literature on Pasteurellaceae family.
- Analysis of pathogenic mechanisms including endotoxins and protein toxins.
- Examination of disease manifestations and host-immune responses.
Main Results:
- Pasteurellaceae pathogenesis involves inflammatory responses, primarily mediated by endotoxin and protein toxins.
- Disease patterns include pneumonic/septicemic, upper respiratory, and local/traumatic forms.
- Acquired resistance is predominantly antibody-dependent.
Conclusions:
- Pasteurellaceae infections are complex, influenced by host factors and microbial toxins.
- Understanding pathogenesis is key to managing diseases caused by these bacteria.
- Biotechnological approaches offer promising avenues for developing artificial resistance against Pasteurellaceae diseases.