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Updated: May 29, 2026

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
Published on: February 14, 2018
Comparison of CLSI broth macrodilution and microdilution methods for echinocandin susceptibility testing of 5 Candida
Lawrence H Bopp1, Aldona L Baltch, William J Ritz
1Stratton VA Medical Center, Albany, NY 12208, USA.
Abstract:
In order to compare the Clinical and Laboratory Standards Institute (CLSI) broth macrodilution and microdilution methods of susceptibility testing for echinocandins and yeast, 55 strains of Candida representing 5 species were tested using the CLSI-recommended broth macro- and microdilution methods. Small (1-3 log(2)) but potentially important method-, species-, and drug-dependent differences in MICs were observed.
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