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A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
Published on: February 7, 2015
May abnormal carotid intima-media thickness predict colorectal neoplasm?
Jae Myung Cha1, Joung Il Lee, Kwang Ro Joo
1Department of Gastroenterology, Gang Dong Kyung Hee University Hospital, Kyung Hee University, Seoul, Korea. dramc@hanmail.net
Hepato-Gastroenterology
|September 23, 2011
Summary
This study suggests a link between abnormal carotid intima-media thickness (IMT) and colorectal cancer. Further research is needed to confirm this association between atherosclerosis markers and colorectal neoplasm.
Area of Science:
- Cardiovascular Medicine
- Gastroenterology
- Oncology
Background:
- Atherosclerosis is a known indicator of colorectal neoplasm.
- The relationship between colorectal neoplasm and carotid intima-media thickness (IMT), a marker for atherosclerosis, remains unclear.
Purpose of the Study:
- To investigate the association between abnormal carotid IMT and the presence of colorectal neoplasm.
Main Methods:
- A retrospective review of 192 patients who underwent both colonoscopy and carotid IMT measurement within 3 months.
- Comparison of abnormal carotid IMT prevalence between patients with and without colorectal neoplasm.
Main Results:
- Patients with colorectal adenomas had a 1.5 times greater risk of abnormal IMT.
- Patients with colorectal adenocarcinomas showed a 3.5 times greater risk of abnormal IMT.
- A statistical trend (p=0.072) was observed for the association between abnormal carotid IMT and colorectal adenocarcinoma via multivariate analysis.
Conclusions:
- A statistical trend suggests a link between colorectal adenocarcinoma and abnormal carotid IMT.
- Further prospective studies with larger cohorts are required to validate these findings.
