Genetic predictors of antipsychotic-induced weight gain: a case-matched multi-gene study

To determine associations between weight gain induced by antipsychotic and the polymorphisms of HTR2C gene -759C/T and -697G/C, histamine-1 receptor gene, leptine gene -2548G/A, and adiponectin gene +276G/T and +45T/G.

In the case-matched study, 85 patients who gained more than 7% of their pre-drug body weight served as the study group and another 85 patients who gained less than 7% of their pre-drug body weight served as the control group. The ligation diction reaction technique was used to analyze the frequencies of the -759C/T and -697G/C polymorphism of the HTR2C gene, -2548A/G polymorphism of leptin gene, +276G/T and +45T/G polymorphism of adiponectin gene and glu349asp polymorphism of H1 receptor gene.

The presence of the -759C allele, -697G allele, -2548A allele and +276G allele was significantly higher in the study group than that in the control group (P<0.05).

The -759C/T and -697G/C polymorphisms of the promoter region of 5HT(2)C receptor gene, -2548A/G polymorphisms of leptin gene and +276G/T polymorphisms of adiponectin gene may be associated with the antipsychotic induced weight gain. The glu349asp polymorphisms of histamine-1 receptor gene is not associated with antipsychotic induced weight gain.