Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.
Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Circulating propionate and butyrate are associated with metabolic improvements following probiotic and dietary fiber supplementation in patients on antipsychotics: a post-hoc analysis of a randomized controlled trial.

BMC psychiatry·2026
Same author

Highly Dispersed Co/CoO Nanoparticles Anchored on N-Doped Biochar Enhanced Peroxymonosulfate Activation for Efficient Norfloxacin Degradation.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

ESAK-YOLO: multi-scale attention enhanced object detection for floating waste in complex water scenes.

Scientific reports·2026
Same author

Altered Effective Connectivity of Precuneus Subregions and Associated Gene Profiles in Chronic Insomnia Disorder Patients Before and After Treatment.

Brain and behavior·2026
Same author

Effects of electroconvulsive therapy on cerebellar-cerebral functional connectivity in patients with treatment-resistant depression and their correlations with gene expression profiles.

Psychiatry and clinical neurosciences·2026
Same author

Preliminary Study of Main Pathogenicity Factors and Metabolites of <i>Wilsonomyces carpophilus</i>.

Plants (Basel, Switzerland)·2026
Same journal

A case report of atypical optic neuritis.

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences·2026
Same journal

[Application of optical genome mapping technology in the genetic diagnosis of a family with a cryptic complex chromosomal balanced translocations].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences·2026
Same journal

[<i>CNKSR2</i> gene variants causing Houge type of X-linked syndromic intellectual developmental disorder: Seven cases and literature review].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences·2026
Same journal

[D-wave-guided navigation in spinal cord surgery: From monitoring to decision-making].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences·2026
Same journal

[Latent profile analysis of mental health literacy among nurses in tertiary general hospitals in Chongqing, China].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences·2026
Same journal

Sex differences in the global burden of autism spectrum disorders: An analysis based on GBD 2021 data.

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences·2026
See all related articles

Related Experiment Video

Updated: May 29, 2026

Development of a Virtual Reality Assessment of Everyday Living Skills
10:32

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

Cognitive functioning in schizophrenia with or without diabetes.

Xiaofeng Guo1, Zhanchou Zhang, Weiwei Zhu

  • 1Central South University, Changsha 410011, China.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|September 23, 2011
PubMed
Summary
This summary is machine-generated.

Schizophrenia patients with diabetes exhibit more severe cognitive impairments than those without diabetes. Managing diabetes may improve cognitive function in schizophrenia patients.

More Related Videos

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
07:41

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

Related Experiment Videos

Last Updated: May 29, 2026

Development of a Virtual Reality Assessment of Everyday Living Skills
10:32

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
07:41

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

Area of Science:

  • Neuroscience
  • Psychiatry
  • Endocrinology

Background:

  • Schizophrenia is a complex mental disorder.
  • Diabetes mellitus is a common comorbidity in schizophrenia patients.
  • The impact of diabetes on cognitive function in schizophrenia is not fully understood.

Purpose of the Study:

  • To investigate the influence of comorbid diabetes on cognitive function in patients with schizophrenia.
  • To compare cognitive performance between schizophrenia patients with and without diabetes.

Main Methods:

  • A cohort of 78 schizophrenia patients with diabetes and 118 schizophrenia patients without diabetes was recruited.
  • Cognitive functions were assessed using standardized tests including the Wechsler Memory Scale-Revised, Wechsler Adult Intelligence Scale-Revised, Computerized Wisconsin Card Sorting Test, and Trail Making Tests.
  • Clinical symptoms were evaluated using the Negative and Positive Syndrome Scale.

Main Results:

  • Schizophrenia patients with diabetes showed significantly poorer performance in processing speed, attention/working memory, executive functioning, and visual memory compared to schizophrenia patients without diabetes (P<0.05).
  • Scores on the Wechsler Adult Intelligence Scale-Revised Digit Symbol Test and Trail Making Tests A and B were significantly associated with diabetes duration and age at onset (P<0.01).

Conclusions:

  • Comorbid diabetes exacerbates cognitive deficits in schizophrenia patients.
  • Effective prevention and management of diabetes are crucial for improving cognitive outcomes in individuals with schizophrenia.