Related Experiment Video

Updated: May 29, 2026

Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies
07:55

Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies

Published on: August 29, 2017

A novel strategy for exploring the reassortment origins of newly emerging influenza virus

Deqiao Tian1, Yumin Wang, Tao Zheng

  • 1Beijing Institute of Biotechnology, Beijing 100071, China.

Bioinformation
|September 23, 2011
PubMed

Insights

Investigating the 2009 swine-origin influenza A (H1N1) virus, this study examines segment reassortment origins. The findings offer a method to trace reassortment in novel influenza viruses for better control.

Area of Science:

  • Virology
  • Molecular Biology
  • Epidemiology

Background:

  • The 2009 swine-origin influenza A (H1N1) virus caused a global pandemic, highlighting the need to understand its origins for effective control.
  • Influenza viruses possess eight genetic segments, facilitating reassortment, a key driver of viral evolution and emergence.
  • Identifying the parental sources of each segment is crucial for understanding the evolutionary pathways of novel influenza strains.

Purpose of the Study:

  • To explore the multilevel reassortment origins of the 2009 H1N1 influenza virus.
  • To develop and validate a strategy for identifying reassortment origins in emerging influenza viruses.

Main Methods:

  • Comparative analysis of the genetic segment origins of the 2009 H1N1 influenza virus.
  • Assessing segment homology with potential parental strains to infer reassortment events.
  • Validating the proposed strategy for its reliability in determining reassortment origins.

Main Results:

  • The study proposes a method based on segment-specific homology analysis to trace reassortment origins.
  • Demonstrates the application of this method to the 2009 H1N1 influenza virus.
  • Provides evidence for the utility of this approach in understanding complex viral reassortment.

Conclusions:

  • The multilevel reassortment analysis provides insights into the evolutionary origins of the 2009 H1N1 influenza virus.
  • The validated strategy can be a valuable tool for investigating the reassortment origins of newly emerging influenza viruses.
  • Understanding reassortment mechanisms is vital for pandemic preparedness and response.
Keywords:
influenza virusorigin sourcesreassortment

More Related Videos

Intranasal Administration of Recombinant Influenza Vaccines in Chimeric Mouse Models to Study Mucosal Immunity10:39

Intranasal Administration of Recombinant Influenza Vaccines in Chimeric Mouse Models to Study Mucosal Immunity

Published on: June 25, 2015

Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit22:10

Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit

Published on: June 28, 2013

Related Concept Videos

Viral Recombination00:57

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
Viral Mutations00:36

Viral Mutations

A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material for adaptive...