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Next-generation Sequencing

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.

Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

Protein Networks

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

Protein Networks

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

Sanger Sequencing

Sanger Sequencing

DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...

Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Related Experiment Video

Updated: May 29, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

Trends and developments in bioinformatics in 2010: prospects and perspectives.

C F Aliferis¹, A V Alekseyenko, Y Aphinyanaphongs

¹Center for Health Informatics and Bioinformatics, New York University, New York, NY 10016, USA. constantin.aliferis@nyumc.org

Yearbook of Medical Informatics

|September 23, 2011

Summary

Bioinformatics advancements, driven by Next Generation Sequencing, accelerate progress in biology and translational medicine. However, ensuring robust methods and best practices is crucial to prevent scientific setbacks.

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Area of Science:

Bioinformatics
Computational Biology
Translational Medicine

Background:

Bioinformatics is integral to modern biological and medical research.
The field is rapidly evolving due to technological advancements.

Purpose of the Study:

To survey major developments and trends in Bioinformatics in 2010.
To analyze long-term trends, best practices, and the quality of informatics science.

Main Methods:

A critical review of Bioinformatics literature from the past year.

Main Results:

Next Generation Sequencing is a primary driver of progress in Biology and Translational Medicine.
Rapid development of bioinformatics methods is necessitated by new assaying technologies.
Deficiencies in informatics methods can have severe consequences, highlighting the need for best practices.

Conclusions:

New bioinformatics methods are emerging, paving the way for advancements in biomedicine.
Significant challenges remain, ensuring the continued vitality and importance of the field.