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Related Experiment Video

Updated: May 29, 2026

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes

Published on: September 15, 2018

Familial hypercholesterolemia: present and future management.

B Sjouke¹, D M Kusters, J J P Kastelein

¹Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.

Current Cardiology Reports

|September 23, 2011

Summary

This summary is machine-generated.

Familial hypercholesterolemia (FH) patients need new treatments beyond statins to lower low-density lipoprotein cholesterol (LDL-C) and prevent cardiovascular disease (CVD). Emerging therapies, including mRNA antisense, show promise for managing severe dyslipidemia in FH.

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LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

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Last Updated: May 29, 2026

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes

Published on: September 15, 2018

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

Area of Science:

Cardiovascular Medicine
Metabolic Disorders
Pharmacology

Background:

Familial hypercholesterolemia (FH) is a genetic disorder causing high LDL-C levels.
Elevated LDL-C significantly increases the risk of premature cardiovascular disease (CVD).
Current treatments, primarily statins, may not be sufficient for all FH patients.

Purpose of the Study:

To review advancements in understanding LDL metabolism.
To explore novel therapeutic targets and treatment modalities for FH.
To assess the potential of emerging therapies in managing FH.

Main Methods:

Review of recent scientific literature on FH, LDL metabolism, and novel therapies.
Analysis of emerging treatment modalities, including mRNA antisense therapy.
Evaluation of clinical evidence for novel agents in lowering LDL-C.

Main Results:

Significant progress has been made in identifying new therapeutic targets for FH.
Novel treatment modalities, such as mRNA antisense therapy, are emerging.
Some new therapies demonstrate effectiveness in reducing plasma LDL-C levels.

Conclusions:

Emerging therapies hold promise for FH patients, particularly those unresponsive to or intolerant of statins.
New treatments are expected to enhance the management of severe dyslipidemia in FH.
Advancements in LDL metabolism research are paving the way for future therapeutic strategies against CVD.