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Related Concept Videos

Methods for Studying Drug Absorption: In situ01:09

Methods for Studying Drug Absorption: In situ

In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
Methods for Studying Drug Absorption: In vitro01:16

Methods for Studying Drug Absorption: In vitro

In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
Non-Oral Extravascular Drug Absorption Routes01:15

Non-Oral Extravascular Drug Absorption Routes

Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more effectively...
Drug Absorption Mechanism: Passive Membrane Transport01:23

Drug Absorption Mechanism: Passive Membrane Transport

Passive transport is a method of drug absorption where small, lipid-soluble drugs can move across the cell membrane. This movement happens along the concentration gradient, which is a natural flow from higher to lower concentration areas. The speed at which the drug moves is directly related to its lipid–water partition coefficient. This means that the more a drug dissolves in lipids, the faster it diffuses or spreads throughout the body. It is important to note that most drugs are either weak...
Drug Absorption: Overview01:17

Drug Absorption: Overview

The process of drug absorption signifies the transition of a drug from its site of administration into the plasma. This process is influenced by various factors, including the route of administration, the anatomy of the absorption site, the mechanism of absorption, gut motility, and the drug's physicochemical properties.
When drugs are injected intravenously, they directly enter the systemic circulation. Alternatively, orally administered drugs navigate through the gastrointestinal (GI) tract.
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...

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Related Experiment Video

Updated: May 29, 2026

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates
10:33

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

Published on: February 23, 2018

An update on computational oral absorption simulation.

Jennifer B Dressman1, Kirstin Thelen, Stefan Willmann

  • 1Johann Wolfgang Goethe University, Institute of Pharmaceutical Technology, Biocenter, Germany. dressman@em.uni-frankfurt.de

Expert Opinion on Drug Metabolism & Toxicology
|September 24, 2011
PubMed
Summary

Computational models, especially physiologically based pharmacokinetic (PBPK) modeling, are advancing drug absorption prediction. These tools enhance understanding of factors influencing oral drug absorption and aid in drug development.

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Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols
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Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols

Published on: May 20, 2016

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Last Updated: May 29, 2026

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates
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A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

Published on: February 23, 2018

Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols
15:04

Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols

Published on: May 20, 2016

Area of Science:

  • Pharmacokinetics and Drug Development

Background:

  • Computational models have significantly evolved, aiding the understanding of physiological, physicochemical, and formulation impacts on oral drug absorption.
  • Complex computer-based absorption models are now standard in academic research and the pharmaceutical industry.

Purpose of the Study:

  • To review the progress of computational tools for predicting drug absorption.
  • To summarize qualitative and quantitative approaches, focusing on physiologically based pharmacokinetic (PBPK) modeling.
  • To evaluate recent applications and discuss the current state and future improvements of computational absorption models.

Main Methods:

  • Summary of various qualitative and quantitative computational approaches.
  • In-depth description of physiologically based pharmacokinetic (PBPK) modeling theories.
  • Evaluation of recent applications in drug research and development.

Main Results:

  • Physiologically based pharmacokinetic (PBPK) models are key tools for predicting oral drug absorption.
  • Recent applications demonstrate improved prediction accuracy and mechanistic interpretation of experimental data.
  • The field of pharmacokinetics modeling has transformed, with ongoing exciting developments.

Conclusions:

  • Pharmacokinetics modeling has undergone significant transformation in the last 10-20 years.
  • The availability of generic PBPK models has led to increased publications showcasing their utility.
  • PBPK models offer improved prediction of oral drug absorption and mechanistic insights.