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Acute phase response in cattle infected with Anaplasma marginale
S Nazifi1, S M Razavi, F Kaviani
1Department of Clinical Studies, School of Veterinary Medicine, Shiraz University, Shiraz, Iran. nazifi@shirazu.ac.ir
Veterinary Microbiology
|September 24, 2011
Summary
Acute phase responses in cattle infected with Anaplasma marginale were evaluated. Serum amyloid A (SAA) concentration increased significantly, indicating it as a sensitive marker for inflammation in bovine anaplasmosis.
Area of Science:
- Veterinary Immunology
- Bovine Pathology
- Parasitology
Background:
- Anaplasma marginale infection in cattle causes significant economic losses.
- Understanding the acute phase response is crucial for diagnosing and managing bovine anaplasmosis.
Purpose of the Study:
- To evaluate acute phase responses in cattle naturally infected with Anaplasma marginale.
- To assess serum sialic acids, inflammatory mediators (IFN-γ, TNF-α), and acute phase proteins (Hp, SAA) as indicators of disease.
Main Methods:
- Analysis of serum sialic acids, IFN-γ, TNF-α, Hp, and SAA in 20 infected and 10 healthy cattle.
- Hematological parameters (RBC, PCV, Hb) were measured.
- Cattle were categorized based on parasitemia levels (<20% and >20%).
Main Results:
- Infected cattle showed decreased RBC, PCV, and Hb compared to controls.
- Elevated concentrations of Hp, SAA, ceruloplasmin, fibrinogen, serum sialic acids, IFN-γ, and TNF-α were observed in infected animals (P<0.05).
- Serum amyloid A (SAA) emerged as the most sensitive indicator of inflammation.
Conclusions:
- Anaplasma marginale infection triggers a significant acute phase response in cattle.
- Increased SAA concentration is a reliable indicator of the inflammatory process in bovine anaplasmosis.
- Monitoring SAA levels can aid in diagnosing and managing cattle infected with Anaplasma marginale.
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