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Updated: May 29, 2026

A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium
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A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium

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Ano-neorectal function using manometry on patients after restorative proctocolectomy and ileal J-pouch anal

Ryouichi Tomita1, Taro Ikeda, Shigeru Fujisaki

  • 1Department of Surgery, Nippon Dental University School of of Life Dentistry, Tokyo, Japan. rtomita-ndus@mvg.biglobe.ne.jp

Hepato-Gastroenterology
|September 24, 2011
PubMed

Insights

Pediatric patients with soiling after ileal J-pouch anal anastomosis (IPAA) show anal sphincter and neorectal sensory dysfunction. These issues may stem from damage to the ano-neorectal apparatus during surgery for ulcerative colitis (UC).

Area of Science:

  • Pediatric surgery
  • Gastroenterology
  • Colorectal surgery

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory bowel disease.
  • Restorative colectomy with ileal J-pouch anal anastomosis (IPAA) is a surgical option for UC.
  • Post-surgical ano-neorectal function is crucial for patient outcomes.

Purpose of the Study:

  • To evaluate ano-neorectal functions in pediatric patients after IPAA for UC.
  • To compare short-term soiling (6 months) with long-term continence (3 years) post-IPAA.
  • To identify functional deficits associated with soiling after IPAA.

Main Methods:

  • Mamometric study of 10 pediatric patients post-IPAA for UC (ages 10-16).
  • Group A: 6 months post-IPAA (soiling), Group B: 3 years post-IPAA (continence).
  • Group C: 12 healthy controls (ages 12-16).

Main Results:

  • Group A had significantly lower maximum anal sphincter pressures (rest and voluntary contraction) than Groups B and C.
  • Group A exhibited a significantly higher minimum neorectal sensory threshold volume.
  • No significant differences were found in neorectal compliance or neorectoanal inhibitory reflex rates.

Conclusions:

  • Soiling at 6 months post-IPAA is linked to anal sphincter and neorectal sensory dysfunction.
  • Surgical factors like short rectal cuff and mucosectomy during IPAA may damage the ano-neorectal apparatus.
  • Functional recovery and continence improve by 3 years post-IPAA, suggesting potential for adaptation or healing.
Abstract

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