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Updated: May 29, 2026

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
Published on: November 22, 2024
Atherosclerosis and dementia: a cross-sectional study with pathological analysis of the carotid arteries
Claudia K Suemoto1, Ricardo Nitrini, Lea T Grinberg
1Department of Geriatrics, University of Sao Paulo Medical School, Avenida Doutor Arnaldo, 455, sala 1353, São Paulo, SP, Brazil. cksuemoto@usp.br
Background And Purpose:
Previous ultrasound-based studies have shown an association between carotid artery atherosclerosis and dementia. Our aim was to investigate this association using postmortem examination.
Methods:
Postmortem morphometric measurements of carotid stenosis and intima-media thickness were performed in individuals with dementia (n=112) and control subjects (n=577). Multivariate logistic regression models were applied.
Results:
High-grade left internal carotid stenosis (≥70%) was associated with increased odds for dementia (OR, 2.30; 95% CI, 1.14-4.74; P=0.02). Intima-media thickness was not associated with dementia.
Conclusions:
The likelihood of dementia is increased with high-grade left internal carotid artery atherosclerosis after adjusting for demographic and cardiovascular risk factors.
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