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Comprehensive cardiac rehabilitation for secondary prevention after transient ischemic attack or mild stroke: I:
Peter L Prior1, Vladimir Hachinski, Karen Unsworth
1London Health Sciences Centre Cardiac Rehabilitation & Secondary Prevention Program, London, Ontario, Canada.
Insights
Comprehensive cardiac rehabilitation (CCR) effectively improved health markers in stroke patients. This study shows CCR is feasible for secondary stroke prevention, enhancing vascular health.
Area of Science:
- Cardiology
- Neurology
- Preventive Medicine
Background:
- Comprehensive cardiac rehabilitation (CCR) is established for cardiac patients.
- CCR integrates lifestyle changes and medication for improved outcomes.
- Its application in cerebrovascular disease is less explored.
Purpose of the Study:
- To assess the feasibility and effectiveness of a 6-month outpatient CCR program.
- To evaluate CCR for secondary prevention in patients with transient ischemic attack (TIA) or mild stroke.
- To identify changes in vascular risk factors post-CCR.
Main Methods:
- A prospective cohort study design was used.
- 110 patients with TIA or mild stroke and at least one vascular risk factor were recruited.
- Outcomes were measured over a 6-month CCR intervention period.
Main Results:
- 100 patients entered and 80 completed the 6-month CCR program.
- Significant improvements were observed in aerobic capacity, cholesterol levels, triglycerides, and body weight.
- A notable shift towards nonsmoking and improved Duke Treadmill Score were recorded.
Conclusions:
- Outpatient CCR is a feasible and effective intervention for secondary prevention in TIA and mild stroke survivors.
- CCR demonstrates potential for broad vascular protection across different chronic disease populations.
- Further investigation via a randomized trial is underway to confirm these findings.
Background And Purpose:
Comprehensive cardiac rehabilitation (CCR), which integrates structured lifestyle interventions and medications, reduces morbidity and mortality among cardiac patients. CCR has not typically been used with cerebrovascular populations, despite important commonalities with heart patients. We tested feasibility and effectiveness of 6-month outpatient CCR for secondary prevention after transient ischemic attack or mild, nondisabling stroke. This article presents risk factors. A future article will discuss psychological outcomes.
Methods:
Consecutive consenting subjects having sustained a transient ischemic attack or mild, nondisabling stroke within the previous 12 months (mean, 11.5 weeks; event-to-CCR entry) with ≥1 vascular risk factor, were recruited from a stroke prevention clinic providing usual care. We measured 6-month CCR outcomes following a prospective cohort design.
Results:
Of 110 subjects recruited from January 2005 to April 2006, 100 subjects (mean age, 64.9 years; 46 women) entered and 80 subjects completed CCR. We obtained favorable, significant intake-to-exit changes in: aerobic capacity (+31.4%; P<0.001), total cholesterol (-0.30 mmol/L; P=0.008), total cholesterol/high-density lipoprotein (-11.6%; P<0.001), triglycerides (-0.27 mmol/L; P=0.003), waist circumference (-2.44 cm; P<0.001), body mass index (-0.53 kg/m(2); P=0.003), and body weight (-1.43 kg; P=0.001). Low-density lipoprotein (-0.24 mmol/L), high-density lipoprotein (+0.06 mmol/L), systolic (-3.21 mm Hg) and diastolic (-2.34 mm Hg) blood pressure changed favorably, but nonsignificantly. A significant shift toward nonsmoking occurred (P=0.008). Compared with intake, 11 more individuals (25.6% increase) finished CCR in the lowest-mortality risk category of the Duke Treadmill Score (P<0.001).
Conclusions:
CCR is feasible and effective for secondary prevention after transient ischemic attack or mild, nondisabling stroke, offering a promising model for vascular protection across chronic disease entities. We know of no similar previous investigation, and are now conducting a randomized trial.
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