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Atopic dermatitis and the atopic march: what is new?
Annalisa Patrizi1, Alessandro Pileri, Federica Bellini
1Division of Dermatology, Department of Internal Medicine, Geriatrics and Nephrology, University of Bologna, Via Massarenti 1, 40138 Bologna, Italy.
Journal of Allergy
|September 24, 2011
Summary
Atopic dermatitis (AD) management and allergic respiratory diseases are linked by the atopic march. An impaired epidermal barrier, often due to filaggrin gene mutations, is a key factor initiating this progression.
Area of Science:
- Dermatology
- Allergology
- Genetics
Background:
- Atopic dermatitis (AD) is a chronic inflammatory skin condition.
- AD is frequently associated with allergic respiratory diseases, a phenomenon known as the atopic march.
- Understanding the underlying mechanisms of the atopic march is crucial for effective management and prevention.
Purpose of the Study:
- To review the current management strategies for atopic dermatitis.
- To explore the association between atopic dermatitis and allergic respiratory diseases.
- To elucidate the factors contributing to the initiation of the atopic march.
Main Methods:
- A comprehensive literature review was conducted using PubMed.
- Articles published within the last 15 years were included.
- Focus was placed on studies investigating the atopic march and its predisposing factors.
Main Results:
- Cross-sectional population studies indicate that reduced filaggrin expression is a significant predisposing factor for atopy.
- An impaired epidermal barrier increases skin permeability to allergens, potentially leading to airway sensitization.
- Filaggrin gene mutations are identified as a major inherited factor contributing to epithelial barrier defects.
Conclusions:
- The atopic march is initiated by an impaired epidermal barrier, allowing allergen penetration and sensitization.
- Genetic factors, particularly filaggrin gene mutations, play a primary role in epithelial barrier dysfunction.
- Further research is necessary to develop targeted AD treatments and preventive strategies for the atopic march.
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