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Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

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Updated: May 29, 2026

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

Genomic analysis at the single-cell level.

Tomer Kalisky¹, Paul Blainey, Stephen R Quake

¹Department of Bioengineering, Stanford University and Howard Hughes Medical Institute, Stanford, California 94305, USA. quake@stanford.edu

Annual Review of Genetics

|September 28, 2011

Summary

This summary is machine-generated.

This review explores single-cell genomic analysis methods for understanding complex biological systems. It covers techniques essential for studying cell behavior and interactions in areas like developmental biology and oncology.

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Last Updated: May 29, 2026

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

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Transcriptome Analysis of Single Cells

Transcriptome Analysis of Single Cells

Published on: April 25, 2011

Area of Science:

Genomics
Cell Biology
Systems Biology

Background:

Complex biological systems (e.g., embryos, tumors, microbial ecosystems) comprise heterogeneous cells with intricate interactions.
Understanding cellular behavior and heterogeneity is crucial for studying these systems.

Purpose of the Study:

To review various approaches to single-cell genomic analysis.
To highlight the importance of single-cell genomics in dissecting complex biological systems.

Main Methods:

Review of existing literature on single-cell genomic analysis techniques.
Discussion of different genomic analysis methodologies applicable at the single-cell level.

Main Results:

Identification of diverse single-cell genomic analysis strategies.
Emphasis on the utility of these methods in characterizing cellular heterogeneity and interactions.

Conclusions:

Single-cell genomic analysis provides powerful tools for advancing our understanding of complex biological systems.
Further development and application of these techniques are vital for progress in fields like developmental biology, cancer research, and ecology.