Related Experiment Video
Updated: May 29, 2026

Single Oocyte Bisulfite Mutagenesis
Published on: June 27, 2012
Genomic imprinting: a mammalian epigenetic discovery model
1CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. dbarlow@cemm.oeaw.ac.at
Genomic imprinting, an epigenetic process, reveals how DNA methylation silences genes. Macro noncoding RNAs (ncRNAs) play a key role in regulating gene expression during development and disease.
Area of Science:
- Epigenetics
- Genomics
- Molecular Biology
Background:
- Genomic imprinting is an epigenetic process controlling parental-specific gene expression in mammals.
- It affects 1-2% of mammalian genes and serves as a model for studying epigenetic regulation in development and disease.
Purpose of the Study:
- To review progress in understanding the silencing mechanisms of imprinted protein-coding genes.
- To highlight the role of macro noncoding RNAs (ncRNAs) in this process.
Main Methods:
- Review of scientific literature on genomic imprinting.
- Focus on epigenetic mechanisms, including DNA methylation and ncRNAs.
Main Results:
- Discovery of long-range cis-acting elements regulating gene clusters.
- Identification of macro ncRNAs that repress genes in cis.
- Demonstration that DNA methylation allows expression of genes normally repressed by default.
Conclusions:
- Genomic imprinting provides insights into epigenetic regulation.
- Macro ncRNAs represent a significant layer of regulatory information in the mammalian genome.
- Understanding these mechanisms is crucial for development and disease research.
More Related Videos
10:41An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
Published on: April 5, 2018
07:50Immunohistochemical Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in Developing and Postmitotic Mouse Retina
Published on: August 29, 2018
Related Concept Videos
Genomic Imprinting and Inheritance
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Epigenetic Regulation
Epigenetic Regulation
X-chromosome...
Epigenetic Regulation
Imprinting
Histone Modification
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...