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Therapeutic potential for HDAC inhibitors in the heart

Timothy A McKinsey1

  • 1Department of Medicine, Division of Cardiology, University of Colorado Denver, Aurora, Colorado 80045-0508, USA. timothy.mckinsey@ucdenver.edu

Annual Review of Pharmacology and Toxicology
|September 28, 2011
PubMed

Insights

Histone deacetylase (HDAC) inhibitors, initially developed for cancer, show promise for treating heart failure. This review explores HDACs

Area of Science:

  • Biochemistry and Molecular Biology
  • Cardiovascular Research
  • Pharmacology

Background:

  • Protein acetylation regulates gene expression and cellular signaling.
  • Histone deacetylases (HDACs) are key enzymes in deacetylation.
  • HDAC inhibitors are approved cancer therapeutics with emerging non-oncology applications.

Purpose of the Study:

  • To review the roles of HDACs in cardiac function.
  • To evaluate the therapeutic potential of HDAC inhibitors for heart failure.

Main Methods:

  • Literature review of preclinical and clinical studies.
  • Analysis of existing data on HDAC function in the heart.
  • Synthesis of information on HDAC inhibitor efficacy in heart failure models.

Main Results:

  • HDACs play significant roles in cardiac physiology and pathophysiology.
  • Preclinical studies demonstrate efficacy of HDAC inhibitors in heart failure models.
  • HDAC inhibition may offer a novel therapeutic strategy for heart failure.

Conclusions:

  • HDACs are critical regulators in the heart.
  • HDAC inhibitors represent a promising therapeutic avenue for heart failure.
  • Further research is warranted to translate these findings into clinical practice.

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