Relationship between reproductive aging, body composition, hormonal status and metabolic syndrome in postmenopausal
S Ziaei1, M Sayahi, S Faghihzadeh
1Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran.
Objective:
To determine the relationship between different anthropometric indicators, reproductive aging and hormonal status in postmenopausal women with and without metabolic syndrome.
Methods:
One hundred and forty non-surgical, postmenopausal women were enrolled to this cross-sectional study. Each participant completed a questionnaire and underwent a medical examination, including measurements of body mass index, weight and body composition criteria. Body composition was evaluated with measurements of the waist-to-hip circumference ratio and skinfold thickness (triceps, suprailiac and front thigh). Levels were determined of serum lipids, including cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol and triglycerides, and also fasting blood sugar, sex hormone binding globulin (SHBG), estradiol and testosterone. The metabolic syndrome was defined according to the definition of the National Cholesterol Education Program Adult Treatment Panel III.
Results:
Logistic regression analysis revealed a significant association between weight (p < 0.001), age (p < 0.01) and SHBG (p = 0.021) with risk for metabolic syndrome.
Conclusion:
Age, SHBG and weight are critical correlates of metabolic syndrome in postmenopausal women.
Related Concept Videos
Menopause
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
The Effect of Aging on Tissues
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
Oogenesis
