Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Compact Bone01:27

Compact Bone

Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Spongy Bone01:09

Spongy Bone

All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stability and complications following mandibular supra-foraminal high oblique osteotomy.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery·2026
Same author

Incidence and risk factors for recurrence, metastasis, and malignant transformation of ameloblastoma.

International journal of oral and maxillofacial surgery·2026
Same author

Virtual reality delivers comparable insights to traditional techniques in maxillofacial trauma education.

Journal of stomatology, oral and maxillofacial surgery·2026
Same author

Penicillin reintroduction using the PEN-FAST score reduces infectious complications in maxillofacial surgery.

Journal of stomatology, oral and maxillofacial surgery·2026
Same author

Diagnosis and management of orbital compartment syndrome caused by retrobulbar hematoma following orbital fractures.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery·2026
Same author

Head and neck penetrating trauma caused by airbag dysfunction: A case series and literature review.

Annales de chirurgie plastique et esthetique·2026
Same journal

[Proceedings of the 48th Congress SFSCMF Surgery and pre-implantation and implantology,27–29 September 2012, Versailles, France].

Revue de stomatologie et de chirurgie maxillo-faciale·2013
Same journal

[Contribution and limitations of MIS(®) screwed expanders in the jaws: illustration from clinical cases and comparison of the osseous volume from three-dimensional radiographic pictures].

Revue de stomatologie et de chirurgie maxillo-faciale·2012
Same journal

[Complications of head and neck skin expansion].

Revue de stomatologie et de chirurgie maxillo-faciale·2012
Same journal

[Complex fronto-orbital reconstruction with a PEEK prosthesis and skin expansion: about a case].

Revue de stomatologie et de chirurgie maxillo-faciale·2012
Same journal

[PEEK customized implant for skull esthetic reconstruction].

Revue de stomatologie et de chirurgie maxillo-faciale·2012
Same journal

[Subcutaneous malar nodule].

Revue de stomatologie et de chirurgie maxillo-faciale·2012
See all related articles

Related Experiment Video

Updated: May 29, 2026

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology
07:26

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology

Published on: August 22, 2022

[Jaw osteosarcomas].

M Steve1, D Ernenwein, A Chaine

  • 1Service de stomatologie et chirurgie maxillo-faciale, hôpital de la Pitié-Salpêtrière, Assistance publique-Hôpitaux de Paris, université Pierre-et-Marie-Curie Paris-6, 47-83 boulevard de l'Hôpital, Paris cedex 13, France.

Revue De Stomatologie Et De Chirurgie Maxillo-Faciale
|September 28, 2011
PubMed
Summary
This summary is machine-generated.

Osteosarcoma of the jaw in adults is rare, often presenting as swelling. Surgical removal with chemotherapy offers a 50% survival rate, but maxillary location and tumor type impact prognosis.

More Related Videos

3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects
08:15

3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects

Published on: August 4, 2020

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Related Experiment Videos

Last Updated: May 29, 2026

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology
07:26

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology

Published on: August 22, 2022

3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects
08:15

3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects

Published on: August 4, 2020

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Area of Science:

  • Oncology
  • Maxillofacial Surgery
  • Bone Tumors

Background:

  • Osteosarcoma (OS) is a rare but aggressive bone malignancy.
  • Facial bone OS constitutes a small percentage of all OS cases, with limited published data.
  • Adult patients with jaw OS require specific management strategies due to anatomical challenges.

Purpose of the Study:

  • To retrospectively analyze adult cases of facial bone osteosarcoma.
  • To compare findings with existing literature.
  • To propose an optimal management scheme for jaw OS.

Main Methods:

  • Retrospective analysis of 33 patients diagnosed with OS between 1997-2007.
  • Inclusion of 14 adult patients with maxillary and mandibular OS treated primarily.
  • Data analyzed included demographics, clinical presentation, radiological findings, and treatment outcomes.

Main Results:

  • The average age of diagnosis was 43 years, with swelling as the most common symptom.
  • CT scans aided diagnosis in 57.1% of cases; biopsy confirmation was 78.6%.
  • The 5-year survival rate was 50%, with surgery and chemotherapy being the standard treatment.

Conclusions:

  • Jaw OS presents unique challenges due to its location and bone structure.
  • Neoadjuvant chemotherapy may reduce tumor size, but optimal management remains debated.
  • Maxillary location, tumor size, and osteoblastic subtype are negative prognostic factors.