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Updated: May 29, 2026

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
Published on: April 11, 2025
[Three-dimensional imaging in cardiac resynchronization therapy]
Dominique Auger1, Martin J Schalij, Jeroen J Bax
1Department of Cardiology, Leiden University Medical Centre, Leiden, Países Bajos.
Insights
Cardiac resynchronization therapy (CRT) can improve heart failure outcomes, but not all patients benefit. A multimodality imaging approach offers a comprehensive evaluation for better CRT response prediction.
Area of Science:
- Cardiology
- Medical Imaging
Background:
- Cardiac resynchronization therapy (CRT) is a treatment for heart failure that improves symptoms and prognosis.
- Up to 40% of heart failure patients do not respond to CRT, necessitating better patient selection.
- Key factors influencing CRT response include left ventricular dyssynchrony, lead position, and myocardial scar tissue.
Purpose of the Study:
- To evaluate the comprehensive assessment of CRT response determinants using multimodality imaging.
- To explore how 3-dimensional imaging techniques can improve patient selection for CRT.
Main Methods:
- Utilizing 2D echocardiography as an initial assessment tool.
- Employing a multimodality imaging approach, including 3D techniques.
- Assessing left ventricular dyssynchrony, lead position, and myocardial scar tissue.
Main Results:
- A multimodality imaging approach provides a more comprehensive evaluation than 2D echocardiography alone.
- Combining assessments of dyssynchrony, lead position, and scar tissue enhances prediction of CRT response.
- 3D imaging techniques offer detailed insights into the pathophysiological determinants of CRT response.
Conclusions:
- A comprehensive, multimodality imaging strategy is superior for evaluating patients considered for CRT.
- Improved patient selection through advanced imaging may increase CRT response rates.
- Integrating 3D imaging into the assessment of CRT candidates is recommended.
Abstract:
Cardiac resynchronization therapy improves clinical symptoms and prognosis of heart failure patients. However, it has been shown that up to 40% of patients do not respond to this therapy. Three main determinants of cardiac resynchronization therapy response have been identified: left ventricular dyssynchrony, left ventricular lead position, and extent and location of myocardial scar tissue. Two-dimensional echocardiography is the first imaging technique to evaluate patients who may be candidates for cardiac resynchronization therapy. However, a multimodality approach based on 3-dimensional imaging techniques may provide a more comprehensive evaluation of these patients by combining the assessment of the aforementioned pathophysiological determinants of cardiac resynchronization therapy response.
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