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Updated: May 29, 2026
Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
Published on: June 16, 2017
Identification of the bleomycin hydrolase gene as a methylated tumor suppressor gene in hepatocellular carcinoma
Yukiyasu Okamura1, Shuji Nomoto, Masamichi Hayashi
1Department of Surgery II, Graduate School and Medicine, University of Nagoya, Showa-ku, Japan.
Abstract:
In the present study, we sought to identify novel suppressor genes of hepatocellular carcinoma (HCC) using our newly designed triple-combination array. Using this method, the bleomycin hydrolase gene (BLMH) was detected as a candidate suppressor gene. We found that 28 of 48 (58.3%) tumor tissues showed BLMH promoter hypermethylation, and its expression level was significantly reduced in tumor tissues (P=0.001). The present study suggests that our new method can detect novel genes of interest and that BLMH is a suppressor gene in HCC.
