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Tuberculosis infection in foreign-born children: a screening survey based on skin and blood testing

M Losi1, B M Bergamini, C Venturelli

  • 1Section of Respiratory Diseases, Department of Oncology, Haematology and Respiratory Diseases, University of Modena and Reggio Emilia, Modena, Italy. monica.losi@unimore.it

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
|September 28, 2011
PubMed

Insights

This study evaluated the QuantiFERON®-TB Gold In-Tube blood test for diagnosing latent tuberculosis infection (LTBI) in foreign-born children. The findings reveal both benefits and drawbacks of using this assay in a two-step diagnostic approach.

Area of Science:

  • Infectious Diseases
  • Immunology
  • Pediatrics

Background:

  • Tuberculosis (TB) remains a global health concern, particularly in high-prevalence countries.
  • Immigration from high TB prevalence regions necessitates effective screening strategies in low-prevalence countries.
  • Accurate diagnosis of latent TB infection (LTBI) is crucial for preventing active disease progression.

Purpose of the Study:

  • To assess the utility of the QuantiFERON®-TB Gold In-Tube (QFT-GIT) assay for diagnosing LTBI in foreign-born children.
  • To evaluate the performance of QFT-GIT within a 'two-step' diagnostic strategy.
  • To identify potential advantages and concerns associated with using QFT-GIT in this specific pediatric population.

Main Methods:

  • The study involved foreign-born children residing in a low TB prevalence country.
  • The QuantiFERON®-TB Gold In-Tube assay was employed for LTBI diagnosis.
  • A 'two-step' diagnostic strategy incorporating the QFT-GIT was implemented.

Main Results:

  • The QFT-GIT assay demonstrated potential for diagnosing LTBI in foreign-born children.
  • Specific advantages of using the QFT-GIT in this cohort were identified.
  • Certain concerns or limitations regarding the QFT-GIT's application were also highlighted.

Conclusions:

  • The QFT-GIT assay can be a valuable tool for LTBI screening in foreign-born children.
  • Careful consideration of the assay's advantages and concerns is necessary for optimal implementation.
  • Further research may be warranted to refine the use of blood tests in diagnosing LTBI in pediatric immigrant populations.

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