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[Ovulation induction using clomiphene conversion].

U Ulrich1, M Nehmzow, B Krause

  • 1Klinik für Gynäkologie und Geburtshilfe, Ernst-Moritz-Arndt-Universität Greifswald, DDR.

Zentralblatt Fur Gynakologie
|January 1, 1990
PubMed
Summary
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Clomiphene conversion therapy helped some anovulatory, clomiphene-resistant patients achieve pregnancy or ovulation. This method offers a potential alternative to gonadotropins and GnRH pulsatile treatments.

Area of Science:

  • Reproductive Endocrinology
  • Infertility Treatment

Context:

  • Anovulatory infertility affects numerous women.
  • Clomiphene citrate is a first-line treatment but often fails in resistant cases.

Purpose:

  • To evaluate the efficacy of "clomiphene conversion" therapy.
  • To assess its potential as an alternative to gonadotropins and GnRH pulsatile therapy.

Summary:

  • Twenty anovulatory and clomiphene-resistant patients underwent clomiphene conversion.
  • Pregnancies were achieved in 6 patients (30%).
  • Ovulation occurred in 7 patients (35%).

Impact:

  • Clomiphene conversion shows promise for managing clomiphene-resistant anovulatory infertility.

Related Experiment Videos

  • This approach may offer a viable alternative to more complex and expensive treatments.