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Related Concept Videos

Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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Tuberculosis01:23

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Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
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Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
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Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

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Updated: May 29, 2026

A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
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A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis

Published on: March 24, 2017

Informatics resources for tuberculosis--towards drug discovery.

Jagadish Chandrabose Sundaramurthi1, S Brindha, T B K Reddy

  • 1ICMR-Biomedical Informatics Centre, Tuberculosis Research Centre (ICMR), Chennai 600031, India.

Tuberculosis (Edinburgh, Scotland)
|September 28, 2011
PubMed
Summary

Bioinformatics and cheminformatics data integration can accelerate tuberculosis drug discovery. Optimally exploiting existing online databases is key to overcoming lags in developing new treatments for infectious diseases.

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System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
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Last Updated: May 29, 2026

A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
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A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis

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System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
09:57

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

Area of Science:

  • Bioinformatics and Cheminformatics
  • Drug Discovery
  • Tuberculosis Research

Background:

  • Numerous bioinformatics databases and tools exist for Mycobacterium tuberculosis, alongside cheminformatics resources for drug discovery.
  • Despite available resources, the drug discovery process for tuberculosis shows a significant lag, especially for emerging infectious diseases.
  • Over 25 freely accessible online databases for tuberculosis remain underutilized.

Purpose of the Study:

  • To review current developments in tuberculosis bioinformatics.
  • To identify areas where integrating bioinformatics and cheminformatics data can accelerate drug discovery.
  • To propose an informatics-centered approach for drug discovery applicable to other diseases.

Main Methods:

  • Review of existing online bioinformatics and cheminformatics databases and tools for tuberculosis.
  • Analysis of data integration strategies between bioinformatics and cheminformatics resources.
  • Identification of potential bottlenecks and opportunities in the tuberculosis drug discovery pipeline.

Main Results:

  • A gap exists between the availability of tuberculosis-related data resources and their optimal exploitation in drug discovery.
  • Integration of bioinformatics and cheminformatics data presents a promising strategy to accelerate the identification and development of new tuberculosis drugs.
  • Current resources have not been fully leveraged to their potential.

Conclusions:

  • Informatics-centered drug discovery, by integrating bioinformatics and cheminformatics data, can bridge the gap and speed up the development of new tuberculosis treatments.
  • Optimal utilization of existing online databases is crucial for advancing tuberculosis drug discovery.
  • The proposed integrated approach can be adapted for accelerating drug discovery in other infectious diseases.