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Updated: May 29, 2026
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Urethral Stricture Induction Followed by Buccal Mucosa Graft Urethroplasty in a Rat Model
Published on: April 28, 2023
Changes in uroflowmetry maximum flow rates after urethral reconstructive surgery as a means to predict for stricture
Bradley A Erickson1, Benjamin N Breyer, Jack W McAninch
1Department of Urology, University of California, San Francisco, San Francisco, California, USA. brad-erickson@uiowa.edu
The Journal of Urology
|September 28, 2011
Summary
Changes in uroflowmetry (urine flow rate) can reliably screen for urethral stricture recurrence after surgery. A drop of less than 10 ml/sec in flow rate indicates a high likelihood of recurrence.
Area of Science:
- Urology
- Surgical Outcomes
- Diagnostic Methods
Background:
- Urethral stricture recurrence after urethroplasty necessitates reliable, noninvasive screening.
- Uroflowmetry is a potential noninvasive tool for monitoring post-surgical outcomes.
Purpose of the Study:
- To investigate if changes in uroflowmetry relative to preoperative values can predict urethral stricture recurrence after urethroplasty.
- To establish uroflowmetry as a screening method for post-urethroplasty stricture recurrence.
Main Methods:
- Retrospective analysis of 125 men undergoing urethroplasty from 2000-2009 with pre- and post-operative uroflowmetry.
- Comparison of maximum flow rates to identify changes indicative of recurrence, validated by retrograde urethrogram.
- Assessment of uroflowmetry reproducibility with repeated postoperative measurements.
Main Results:
- A significant difference in maximum flow rate change was observed between patients with (0.2 ± 6.4 ml/sec) and without recurrence (19.2 ± 11.7 ml/sec, p <0.001).
- A threshold change of <10 ml/sec demonstrated 92% sensitivity and 78% specificity for detecting recurrence.
- Uroflowmetry showed reasonable test reproducibility (r = 0.52) in patients without recurrence.
Conclusions:
- Post-reconstruction changes in urine flow rate are a promising, noninvasive metric for screening urethral stricture recurrence.
- Uroflowmetry offers a sensitive and reproducible method for monitoring patients after urethroplasty.
- This method aids in early detection and management of potential stricture recurrence.
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