Related Experiment Video
Updated: May 29, 2026

Evaluating Postural Control and Lower-extremity Muscle Activation in Individuals with Chronic Ankle Instability
Published on: September 18, 2020
Incident preclinical mobility disability (PCMD) increases future risk of new difficulty walking and reduction in
Carlos O Weiss1, Jennifer L Wolff, Brian Egleston
1Johns Hopkins School of Medicine, 5200 Eastern Avenue, Baltimore, MD 21224-2734, USA. cweiss9@jhmi.edu
Purpose:
This study examines whether and how report of a change in walking behavior, incident PCMD, predicts subsequent reduction in walking activity.
Materials And Methods:
Data are from a prospective study of 436 community-dwelling women age 70-79 years. Outcome measures include subjective and objective measures of walking ability at 3 years.
Principal Results:
Incident PCMD is associated with the loss of walking abilities at 3-years, regardless of baseline physical impairment. Compared to women without, women with incident PCMD at 1.5 years after baseline were 2.7 (95%CI 1.4-7.2) times more likely to report that they no longer walk outdoors at least 8 blocks and 4.9 (1.9-13.1) times more likely to report new difficulty walking. Incident PCMD was also associated with declines in objective outcomes. Incident PCMD is an independent marker of subsequent decreased walking activity.
Major Conclusions:
Incident PCMD appears to be a target for programs to prevent declines in walking activity in older adults.
Related Concept Videos
Peripheral Artery Disease I: Introduction
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Peripheral Artery Disease III: Interprofessional Care

