Related Experiment Video
Updated: May 29, 2026
Mouse In Vivo Placental Targeted CRISPR Manipulation
Published on: April 14, 2023
Global hormone profiling of murine placenta reveals Secretin expression
K Knox1, D Leuenberger, A A Penn
1Department of Genetics, Stanford University, Stanford, CA 94062, USA.
Objective:
To elucidate and categorize the murine placental hormones expressed across gestation, including the expression of hormones with previously undescribed roles.
Study Design:
Expression levels of all genes with known or predicted hormone activity expressed in two separate tissues, the placenta and maternal decidua, were assessed across a timecourse spanning the full lifetime of the placenta. Novel expression patterns were confirmed by in situ hybridization and protein level measurements.
Results:
A combination of temporal and spatial information defines five groups that can accurately predict the patterns of uncharacterized hormones. Our analysis identified Secretin, a novel placental hormone that is expressed specifically by the trophoblast at levels many times greater than in any other tissue.
Conclusions:
The characteristics of Secretin fit the paradigm of known placental hormones and suggest that it may play an important role during pregnancy.
