Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Isolated shoulder palsy due to cortical infarction: localisation and electrophysiological correlates of recovery.

BMJ case reports·2025
Same author

Outcome of fetuses with early increased nuchal translucency: systematic review and meta-analysis.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2025
Same author

Accuracy of cell-free fetal DNA in detecting chromosomal anomalies in women experiencing miscarriage: systematic review and meta-analysis.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2024
Same author

Diagnostic accuracy of cell-free fetal DNA in maternal blood in detecting chromosomal anomalies in twin pregnancy: systematic review and meta-analysis.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2024
Same author

Reliability of Functional and Diffusion MR Imaging Near Cerebral Cavernous Malformations.

AJNR. American journal of neuroradiology·2023
Same author

Cerebral vasculitis due to nickel hypersensitivity: a case of intracranial "device syndrome".

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2022

Related Experiment Video

Updated: May 29, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Diffusion tensor imaging of subependymal heterotopia.

C Briganti1, R Navarra, C Celentano

  • 1Department of Neuroscience and Imaging, University G. D'Annunzio, Chieti, Italy.

Epilepsy Research
|September 28, 2011
PubMed
Summary
This summary is machine-generated.

Diffusion tensor imaging revealed reduced fractional anisotropy and altered diffusivity in a newborn with subependymal heterotopia, indicating arrested neuronal migration. These findings suggest DTI can detect white matter changes associated with SE.

More Related Videos

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

Related Experiment Videos

Last Updated: May 29, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

Area of Science:

  • Neuroimaging
  • Developmental Neuroscience
  • Neuronal Migration Disorders

Background:

  • Subependymal heterotopia (SE) is a congenital brain malformation characterized by misplaced gray matter.
  • White matter abnormalities are increasingly recognized in SE, but their in vivo characterization is limited.
  • Diffusion tensor imaging (DTI) is sensitive to microstructural changes in brain tissue.

Purpose of the Study:

  • To investigate white matter microstructural alterations in a newborn with bilateral subependymal heterotopia using DTI.
  • To compare DTI metrics in SE with those in newborns experiencing perinatal asphyxia.

Main Methods:

  • Magnetic resonance imaging (MRI) with diffusion tensor imaging (DTI) was performed on a newborn with bilateral SE.
  • DTI metrics, including fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD), were analyzed.
  • Data were compared to a control group of four newborns with moderate perinatal asphyxia and normal MRI.

Main Results:

  • The newborn with SE exhibited reduced white matter FA.
  • Increased AD and RD were observed in the white matter of the SE patient.
  • These DTI findings differed from the control group with perinatal asphyxia.

Conclusions:

  • The observed DTI changes (reduced FA, increased AD/RD) in SE represent a late in vivo expression of developmental alterations.
  • These findings suggest an underlying arrest of neuronal migration in the intermediate zone.
  • DTI may serve as a valuable tool for assessing white matter integrity in SE.