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Optical microchip array biosensor for multiplexed detection of bio-hazardous agents.

D Bhatta¹, A A Michel, M Marti Villalba

¹Stratophase Ltd., Romsey SO51 9DL, United Kingdom. devaki.bhatta@stratophase.com

Biosensors & Bioelectronics

|September 28, 2011

Summary

This summary is machine-generated.

This study presents a novel optical waveguide array biosensor for rapid, multiplexed detection of multiple bio-hazardous agents. The SpectroSens™ platform enables real-time, label-free identification of diverse threats, including bacterial spores, viruses, and toxins.

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Area of Science:

Optoelectronics
Biosensing
Microfluidics

Background:

Current methods for detecting bio-hazardous agents often lack speed and multiplexing capabilities.
There is a need for robust, portable biodetection systems for security and defense applications.

Purpose of the Study:

To develop and demonstrate an optical waveguide array biosensor for rapid, multiplexed, and label-free detection of multiple bio-hazardous agents.
To validate the SpectroSens™ technology platform for real-time identification of diverse biological threats.

Main Methods:

Utilized SpectroSens™ optical microchip sensors with multiple waveguide channels and Bragg gratings.
Employed selective surface-functionalization with antibodies for specific bio-recognition.
Integrated two microchip sensors into a single disposable cartridge for 16-channel data acquisition.

Main Results:

Demonstrated real-time, multiplexed, label-free detection of 8 different biological agents, including bacterial spores, cells, viruses, and toxins.
Successfully detected simulants (Bacillus atrophaeus spores, Escherichia coli cells, MS2 viruses, ovalbumin) and actual bio-hazardous agents (Bacillus anthracis spores, Franciscella tularensis cells, Vaccinia viruses, ricin toxin).
Achieved detection of 4 agents per consumable using a specific antibody deposition sequence.

Conclusions:

The SpectroSens™ optical waveguide array biosensor is a man-portable and robust platform for multi-analyte biological detection.
The technology shows significant potential for 'detect to warn/treat' biodetection in security and defense operations.
This multidisciplinary approach integrates biology, chemistry, optoelectronics, and microfluidics for advanced biodetection.