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Secondary structures of Tetrahymena thermophila rRNA IVS sequence involved in its self-splicing reactions: a new
G Benedetti1, P De Santis, S Morosetti
1Department of Chemistry, University of Rome I, Italy.
Journal of Biomolecular Structure & Dynamics
|June 1, 1990
Abstract:
The secondary structures of Tetrahymena thermophila rRNA IVS sequence involved in the self-splicing reactions, are theoretically investigated with a refined computer method previously proposed, able to select a set of the deepest free energy RNA secondary structures under constraints of model hypotheses and experimental evidences. The secondary structures obtained are characterized by the close proximity of self-reactions sites and account for double mutations experiments, and differential digestion data.