Related Experiment Video
Updated: May 29, 2026
10:04
Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
Patterns of pulmonary tuberculosis on FDG-PET/CT
Michael Soussan1, Pierre-Yves Brillet, Arsène Mekinian
1Université Paris 13, Faculté de médecine SMBH, Department of Nuclear Medicine, CHU Avicenne, 125 rue de Stalingrad, 93000 Bobigny, France. michael.soussan@avc.aphp.fr
European Journal of Radiology
|September 28, 2011
Summary
This study identified two patterns of pulmonary tuberculosis (TB) on FDG-PET/CT scans. The lung pattern shows localized infection, while the lymphatic pattern indicates systemic, intense infection.
Area of Science:
- Radiology
- Nuclear Medicine
- Infectious Disease
Background:
- Tuberculosis (TB) diagnosis can be challenging.
- FDG-PET/CT is an imaging modality used in various diseases.
Purpose of the Study:
- To describe and differentiate patterns of pulmonary TB using FDG-PET/CT.
- To correlate imaging findings with clinical presentation.
Main Methods:
- Retrospective review of 16 patients with TB who underwent FDG-PET/CT.
- Analysis of clinical, biological, and imaging data.
- Bacteriological or histopathological confirmation in 13 patients; clinical/imaging diagnosis in 3.
Main Results:
- Two distinct patterns identified: lung pattern (9/16) and lymphatic pattern (7/16).
- Lung pattern: predominantly pulmonary symptoms, parenchymal involvement with consolidation/cavitation, moderate lymph node uptake.
- Lymphatic pattern: predominantly systemic symptoms, extra-thoracic involvement, significantly larger and hypermetabolic mediastino-hilar lymph nodes.
Conclusions:
- FDG-PET/CT reveals two distinct patterns of pulmonary TB: a localized lung pattern and a systemic lymphatic pattern.
- The lung pattern is associated with restricted, mild hypermetabolism; the lymphatic pattern with intense, systemic infection.
- Combined interpretation of PET and CT findings enhances diagnostic specificity, particularly for the lung pattern.
More Related Videos
Related Concept Videos
01:26Pulmonary Tuberculosis IV
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
01:31Pulmonary Tuberculosis III
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
01:28Pulmonary Tuberculosis II
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
01:29Pulmonary Tuberculosis I
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
01:28Pulmonary Tuberculosis V
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...