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Related Concept Videos

Paracrine Signaling01:21

Paracrine Signaling

Paracrine signaling allows cells to communicate with their immediate neighbors via secretion of signaling molecules. Such a signal can only trigger a response in nearby target cells because the signal molecules degrade quickly or are inactivated if not taken up. Prominent examples of paracrine signaling include nitric oxide signaling in blood vessels, synaptic signaling of neurons, the blood clotting system, tissue repair/wound healing, and local allergic skin reactions. Nitric oxide as a...
Paracrine Signaling01:21

Paracrine Signaling

Paracrine signaling allows cells to communicate with their immediate neighbors via secretion of signaling molecules. Such a signal can only trigger a response in nearby target cells because the signal molecules degrade quickly or are inactivated if not taken up. Prominent examples of paracrine signaling include nitric oxide signaling in blood vessels, synaptic signaling of neurons, the blood clotting system, tissue repair/wound healing, and local allergic skin reactions. Nitric oxide as a...
Autocrine Signaling01:01

Autocrine Signaling

Autocrine signaling is one of the many signaling mechanisms that function inside multicellular organisms to carry out intercellular communication. In this type of signaling mechanism, the same cell that secretes an extracellular signaling molecule also expresses the receptors to bind and respond to that signaling molecule.
Autocrine Signaling in Macrophages
Under normal physiological conditions, autocrine signaling is essential for maintaining homeostasis. This process is well characterized in...
Autocrine Signaling01:01

Autocrine Signaling

Autocrine signaling is one of the many signaling mechanisms that function inside multicellular organisms to carry out intercellular communication. In this type of signaling mechanism, the same cell that secretes an extracellular signaling molecule also expresses the receptors to bind and respond to that signaling molecule.
Autocrine Signaling in Macrophages
Under normal physiological conditions, autocrine signaling is essential for maintaining homeostasis. This process is well characterized in...
Endocrine Signaling01:45

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
Endocrine Signaling01:45

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.

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Related Experiment Video

Updated: May 29, 2026

A Proximal Culture Method to Study Paracrine Signaling Between Cells
08:17

A Proximal Culture Method to Study Paracrine Signaling Between Cells

Published on: August 28, 2018

Paracrine signaling by progesterone.

Renuga Devi Rajaram1, Cathrin Brisken

  • 1Ecole Polytechnique Fédérale de Lausanne, ISREC - Swiss Institute for Experimental Cancer Research, NCCR Molecular Oncology, SV2832 Station 19, CH-1015 Lausanne, Switzerland.

Molecular and Cellular Endocrinology
|September 28, 2011
PubMed
Summary

Progesterone

Area of Science:

  • Endocrinology and reproductive biology, focusing on steroid hormone action.

Background:

  • Steroid hormones regulate organ development and function, with progesterone crucial for female reproduction.
  • Progesterone's effects are mediated by its receptor, influencing target tissues through intrinsic and paracrine signaling.

Purpose of the Study:

  • To explore the mechanisms of progesterone action, particularly the role of paracrine signaling.
  • To understand how paracrine factors mediate progesterone's diverse effects across different tissues.

Main Methods:

  • The study reviews existing experimental evidence on progesterone signaling pathways.
  • Analysis of cell-intrinsic and paracrine mechanisms involved in progesterone's physiological effects.

Main Results:

  • Progesterone utilizes both cell-intrinsic and paracrine signaling to exert its effects.

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Last Updated: May 29, 2026

A Proximal Culture Method to Study Paracrine Signaling Between Cells
08:17

A Proximal Culture Method to Study Paracrine Signaling Between Cells

Published on: August 28, 2018

Techniques for Imaging Ca2+ Signaling in Human Sperm
07:38

Techniques for Imaging Ca2+ Signaling in Human Sperm

Published on: June 16, 2010

An Ex vivo Model to Study Hormone Action in the Human Breast
12:31

An Ex vivo Model to Study Hormone Action in the Human Breast

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  • Paracrine signaling amplifies local hormonal stimuli, reaching receptor-deficient cells.
  • Tissue-specific and common paracrine factors coordinate progesterone responses in various cell types.

    • Conclusions:

    • Intercellular signaling pathways, including those activated by progesterone, play a significant role in normal development and physiological functions.
    • These signaling pathways are increasingly recognized for their involvement in pathological processes, including tumorigenesis.