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14-3-3 proteins as signaling integration points for cell cycle control and apoptosis

Alexandra K Gardino1, Michael B Yaffe

  • 1Department of Biology, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute for Technology, Cambridge, MA 02139, USA. gardino@mit.edu

Seminars in Cell & Developmental Biology
|September 28, 2011
PubMed

Insights

14-3-3 proteins regulate cell fate by binding to kinases, controlling cell cycle and DNA damage response. Understanding these signaling integrators reveals new therapeutic targets for human diseases.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • 14-3-3 proteins are crucial regulators of cell fate.
  • They bind to phosphorylated proteins, influencing cellular processes.
  • These proteins are involved in cell cycle progression and DNA damage response.

Purpose of the Study:

  • To review the role of 14-3-3 proteins in cell cycle control and apoptosis.
  • To highlight 14-3-3 proteins as signaling integrators.
  • To emphasize the potential of targeting 14-3-3 pathways for human diseases.

Main Methods:

  • Literature review focusing on 14-3-3 dependent pathways.
  • Analysis of 14-3-3 interactions in cell cycle regulation and apoptosis.
  • Discussion of systems-based approaches for signal transduction.

Main Results:

  • 14-3-3 proteins coordinate cell cycle arrest and recovery.
  • They influence apoptotic machinery at multiple regulatory levels.
  • 14-3-3 proteins integrate protein kinase signaling to cellular phenotypes.

Conclusions:

  • 14-3-3 proteins are key regulators of cell fate decisions.
  • Targeting 14-3-3 pathways offers therapeutic potential for diseases.
  • Systems-based approaches are vital for understanding signal transduction networks.

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