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Expression of FGF23/KLOTHO system in human vascular tissue.
Javier Donate-Correa1, Carmen Mora-Fernández, Rafael Martínez-Sanz
1Research Unit, University Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.
International Journal of Cardiology
|September 28, 2011
Summary
The human aorta expresses the FGF23-KLOTHO system, including KLOTHO and specific FGF receptors, and this system is also found in coronary thrombi, suggesting a role in cardiovascular disease.
Area of Science:
- Cardiovascular Biology
- Endocrinology
- Vascular Medicine
Background:
- Fibroblast growth factor (FGF)-23 is linked to cardiovascular issues.
- KLOTHO may protect against endothelial dysfunction.
- FGF23-KLOTHO system expression in human vasculature was previously unproven.
Purpose of the Study:
- To investigate the expression of FGF23, FGF receptors (FGFR), and KLOTHO in human aorta.
- To analyze FGF23-KLOTHO system expression in coronary thrombi.
Main Methods:
- Analysis of thoracic aorta specimens from 44 patients.
- Testing of thrombus material from 2 patients with acute coronary syndrome (ACS).
- Utilized RT-PCR, sequencing, and qRT-PCR for expression analysis.
Main Results:
- KLOTHO and FGFR-1, -3 were detected in human aorta.
- KLOTHO expression was confirmed in occlusive coronary thrombi from ACS patients.
- FGF23 and FGFR4 were not observed; ADAM-17 and IL-10 expression was noted, correlating with KLOTHO levels.
Conclusions:
- Human vascular tissue expresses components of the FGF23-KLOTHO system.
- KLOTHO is present in occlusive coronary thrombi.
- The FGF23-KLOTHO axis may play a role in human vascular pathophysiology and cardiovascular disease.
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