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Related Concept Videos

Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
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Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
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Endoscopic Procedures I: Esophagogastroduodenoscopy01:29

Endoscopic Procedures I: Esophagogastroduodenoscopy

An Esophagogastroduodenoscopy (EGD) is a diagnostic procedure in which an endoscopist uses a flexible, lighted endoscope to visualize the upper gastrointestinal (GI) tract. The procedure includes visualizing the oropharynx, esophagus, stomach, and the first part of the small intestine, the duodenum.
During an EGD, the endoscope can be used to:

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Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
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Published on: May 10, 2024

Eosinophilic oesophagitis: an Irish experience.

Sarah O'Donnell1, Orlaith B Kelly, Niall Breslin

  • 1Department of Gastroenterology, AMNCH, Tallaght, Dublin, Ireland. odonnes2@tcd.ie

European Journal of Gastroenterology & Hepatology
|September 28, 2011
PubMed
Summary

Eosinophilic oesophagitis is a rare esophageal disorder, primarily affecting young males. This study assessed its incidence in southwest Dublin, Ireland, finding it to be uncommon.

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Published on: April 17, 2020

Area of Science:

  • Gastroenterology
  • Histopathology
  • Epidemiology

Background:

  • Eosinophilic oesophagitis (EoE) is a distinct esophageal disorder.
  • Characterized by specific clinical, endoscopic, and histological findings (≥15 eosinophils/HPF).
  • Increasing incidence suggests factors beyond increased recognition.

Purpose of the Study:

  • To determine the incidence of eosinophilic oesophagitis.
  • Study conducted within the catchment area of a tertiary referral hospital in southwest Dublin, Ireland.

Main Methods:

  • Retrospective analysis of esophageal biopsies from January 2000 to July 2008.
  • Identified biopsies with ≥15 eosinophils/HPF in at least two fields.
  • Expert histopathological review for EoE features.

Main Results:

  • 1364 of 11,072 esophageal biopsies (12.3%) showed esophagitis.
  • Only 13 patients (0.1%) met EoE criteria (≥15 eosinophils/HPF).
  • EoE predominantly affected young males (median age 23, M:F ratio 5.5:1).

Conclusions:

  • Eosinophilic oesophagitis is a rare condition.
  • The disorder predominantly affects young men.
  • Findings support a low incidence in the studied population.