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Related Experiment Video

Updated: May 29, 2026

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography

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Published on: February 19, 2014

[Photodynamic therapy for polypoidal choroidal vasculopathy].

Jiang You¹, Xiaojian Guo

¹Department of Ophthalmology, Central South University, Changsha, China. jiangyou@163.com

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences

|September 28, 2011

Summary

Photodynamic therapy (PDT) for polypoidal choroidal vasculopathy (PCV) can reduce lesion leakage and improve or maintain visual acuity. This treatment shows potential for managing PCV effectively.

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Area of Science:

Ophthalmology
Medical Imaging
Laser Therapy

Background:

Polypoidal choroidal vasculopathy (PCV) is a significant cause of vision loss.
Accurate diagnosis of PCV relies on fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA), and optic coherence tomography (OCT).

Purpose of the Study:

To evaluate the efficacy and safety of photodynamic therapy (PDT) in patients diagnosed with PCV.

Main Methods:

Eleven patients with PCV underwent PDT.
Comprehensive assessments including best corrected visual acuity (BCVA), fundus photography, FFA, and ICGA were performed before and after treatment.
Patient follow-up ranged from 6 to 30 months.

Main Results:

One month post-PDT, BCVA showed improvement in 5 eyes and decrease in 3 eyes; leakage reduced in 6 eyes.
At final follow-up, BCVA was stable or improved in 9 eyes, with reduced or absent leakage in 9 eyes.
One case of vitreous hemorrhage occurred, with no other severe adverse effects reported.

Conclusions:

PDT demonstrates potential in controlling PCV by reducing vascular leakage.
The therapy can facilitate the resolution of hemorrhage, edema, and exudates.
PDT may stabilize or enhance visual acuity, presenting a viable treatment option for PCV.