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Cardiovascular changes in infants with beta-hemolytic streptococcus sepsis.

L A Cabal1, B Siassi, C Cristofani

  • 1Department of Pediatrics, University of Southern California School of Medicine, Women's Hospital, Los Angeles 90033.

Critical Care Medicine
|July 1, 1990
PubMed
Summary

This study tracked hemodynamic and biochemical changes in infants with beta-hemolytic streptococcus sepsis. Key differences in blood pressure and acidosis distinguished survivors from nonsurvivors.

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Area of Science:

  • Pediatrics
  • Neonatology
  • Infectious Diseases

Background:

  • Sepsis in infants, particularly from beta-hemolytic streptococcus, poses a significant mortality risk.
  • Understanding the temporal physiological changes in sepsis is crucial for timely intervention.

Purpose of the Study:

  • To define sequential hemodynamic and biochemical changes in infants with beta-hemolytic streptococcus sepsis.
  • To compare these patterns between surviving and nonsurviving infants.

Main Methods:

  • Studied 24 infants with documented sepsis.
  • Collected biophysical and biochemical measurements hourly for 11 hours post-antibiotic initiation.
  • Compared data between survivors (n=11) and nonsurvivors (n=13).

Main Results:

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  • Survivors had higher hematocrit (Hct), systolic, and mean arterial pressures.
  • Nonsurvivors exhibited low blood pressure (BP) with elevated central venous pressure (CVP) and severe metabolic acidosis.
  • Greater arterial-alveolar oxygen gradients were observed in nonsurvivors.

Conclusions:

  • Cardiorespiratory and metabolic alterations can differentiate outcomes in infants with this type of sepsis.
  • Early identification of these physiological patterns may improve sepsis management in neonates.