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Related Experiment Video

Updated: May 29, 2026

Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity

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Naproxen-induced liver injury.

Sharif Ali¹, Jason D Pimentel, Chan Ma

¹Department of Pathology and Laboratory Medicine, Henry Ford Hospital, 2799 West Grand Blvd., Detroit, MI 48202, USA.

Hepatobiliary & Pancreatic Diseases International : HBPD INT

|September 28, 2011

Summary

Naproxen can cause rare liver injury, often presenting as cholestasis and hepatitis. This drug-induced liver damage may take years to fully resolve, highlighting the need for vigilance.

Area of Science:

Hepatology
Pharmacology
Toxicology

Background:

Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to cause liver injury.
Naproxen, a common NSAID, rarely causes liver damage.

Observation:

A 30-year-old woman developed jaundice and severe itching after taking naproxen.
Her liver biopsy showed inflammation, hepatocyte loss, and bile duct damage (ductopenia).

Findings:

The patient's liver injury presented as a mixed pattern of cholestasis and hepatitis.
Liver function tests normalized near completely only after 10 years.
Histopathology revealed progressive loss of interlobular bile ducts.

Implications:

Naproxen-induced liver toxicity is rare but should be considered in cholestatic cases.

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The mixed cholestatic-hepatitic pattern is characteristic.

Complete recovery from naproxen-associated liver damage can be prolonged.