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Related Concept Videos

iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Unrenewable Cells00:50

Unrenewable Cells

In humans, the photoreceptor cells of the eye and sensory hair cells of the ear lack stem cells. These cells are thus unrenewable and cannot be replaced when they are damaged or destroyed.
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of their outer...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

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Related Experiment Video

Updated: May 29, 2026

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model
07:43

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model

Published on: August 5, 2021

Stem cells for retinal replacement therapy.

Jeffrey H Stern1, Sally Temple

  • 1Neural Stem Cell Institute, Rensselaer, NY 12144, USA. retina@nycap.rr.com

Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics
|September 28, 2011
PubMed
Summary
This summary is machine-generated.

Stem cell therapy offers a promising new avenue for treating blinding retinal diseases by replacing damaged cells and providing neuroprotection. Early clinical trials are underway, with anticipated data on safety and efficacy poised to revolutionize treatment approaches.

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Sub-Retinal Delivery of Human Embryonic Stem Cell Derived Photoreceptor Progenitors in rd10 Mice
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Efficient Derivation of Retinal Pigment Epithelium Cells from Stem Cells
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Efficient Derivation of Retinal Pigment Epithelium Cells from Stem Cells

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Last Updated: May 29, 2026

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model
07:43

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model

Published on: August 5, 2021

Sub-Retinal Delivery of Human Embryonic Stem Cell Derived Photoreceptor Progenitors in rd10 Mice
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Sub-Retinal Delivery of Human Embryonic Stem Cell Derived Photoreceptor Progenitors in rd10 Mice

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Efficient Derivation of Retinal Pigment Epithelium Cells from Stem Cells
07:07

Efficient Derivation of Retinal Pigment Epithelium Cells from Stem Cells

Published on: March 8, 2015

Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Neuroscience

Background:

  • Retinal degenerative diseases currently have limited therapeutic options.
  • Stem cell therapy is being explored as a potential regenerative treatment for blinding conditions.
  • The retina and retinal pigment epithelium are accessible targets for stem cell therapeutics.

Purpose of the Study:

  • To explore the potential of stem cell-mediated regenerative treatments for retinal degenerative diseases.
  • To advance strategies combining established surgical approaches with stem cell-derived donor cells.
  • To replace lost or damaged retinal cells and/or provide neuroprotection to improve visual function.

Main Methods:

  • Utilizing a variety of tissue-specific and pluripotent-derived donor cells.
  • Advancing cell transplantation strategies for retinal disease.
  • Conducting early-stage clinical trials to assess safety and efficacy.

Main Results:

  • Stem cell-derived donor cells are being developed to replace retinal cells.
  • Neuroprotective factors are being investigated to slow disease progression.
  • Clinical trials are in early stages, with safety and efficacy data pending.

Conclusions:

  • Stem cell-based approaches hold significant promise for treating blinding retinal disorders.
  • Positive clinical outcomes could fundamentally alter the management of these conditions.
  • Further research and clinical data are crucial for realizing the full potential of stem cell therapeutics in ophthalmology.