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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Advanced technologies for oral controlled release: cyclodextrins for oral controlled release
Paulo José Salústio1, Patrícia Pontes, Claúdia Conduto
1Research Institute for Medicines and Pharmaceutical Sciences, Faculty of Pharmacy, University of Lisbon, Portugal.
AAPS Pharmscitech
|September 28, 2011
Summary
Cyclodextrins (CDs) enhance oral drug delivery by improving solubility and controlling release. These versatile compounds, including nanoparticles, offer improved drug formulation and therapeutic outcomes.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Nanotechnology
Background:
- Cyclodextrins (CDs) are widely utilized in oral pharmaceutical formulations.
- They form inclusion complexes with drugs, offering several advantages.
- Recent advancements explore CDs as nanocarriers for advanced drug delivery systems.
Purpose of the Study:
- To review the applications of cyclodextrins and their derivatives in enhancing solubility of poorly water-soluble drugs.
- To examine the ability of CDs to control drug release profiles from solid dosage forms.
- To explore novel controlled delivery systems based on nanotechnology carriers.
Main Methods:
- Literature review of cyclodextrin applications in pharmaceutical formulations.
- Analysis of studies on inclusion complex formation for solubility and dissolution enhancement.
- Review of nanotechnology-based drug delivery systems utilizing cyclodextrins.
Main Results:
- Cyclodextrins significantly enhance drug solubility, dissolution rate, stability, and bioavailability.
- CDs can modify drug release, reducing gastrointestinal side effects and improving taste/smell.
- Nanotechnology carriers incorporating CDs offer versatile platforms for oral drug delivery.
Conclusions:
- Cyclodextrins are effective excipients for improving oral drug formulation and delivery.
- Their ability to form inclusion complexes and act as nanocarriers provides significant therapeutic advantages.
- Further research into CD-based nanocarriers promises innovative solutions for drug delivery challenges.
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