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Related Experiment Video

Updated: May 29, 2026

Cholesterol Efflux Assay

Cholesterol Efflux Assay

Published on: March 6, 2012

Paediatric screening for hypercholesterolaemia in Europe.

D M Kusters¹, C de Beaufort, K Widhalm

¹Department of Pediatrics, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

Archives of Disease in Childhood

|September 28, 2011

Summary

Current (familial) hypercholesterolaemia screening in children has low adherence and misses many at-risk youth. Universal screening from ages 1-9 may improve early detection of this inherited condition.

Related Experiment Videos

Last Updated: May 29, 2026

Cholesterol Efflux Assay

Cholesterol Efflux Assay

Published on: March 6, 2012

Area of Science:

Pediatrics
Cardiology
Genetics

Background:

Current screening strategies for familial hypercholesterolaemia (FH) in children exhibit low adherence and compliance.
Existing methods often fail to identify a significant number of children at risk for early coronary artery disease.

Purpose of the Study:

To evaluate the effectiveness of current screening strategies for FH in children.
To identify optimal screening approaches for early detection and management of FH in pediatric populations.

Main Methods:

A comprehensive literature review was conducted.
Analysis focused on recommended screening protocols, tools, and their limitations in Europe.
Assessment included the precision of selective screening based on family history.

Main Results:

Selective screening strategies, primarily family history-based, lack precision in identifying children with FH.
A substantial proportion of children with FH, at risk for future cardiovascular disease, remain undetected.
Current European screening tools and strategies have documented negative aspects.

Conclusions:

Recommended selective screening for FH in children is imprecise and identifies only a fraction of affected individuals.
Universal screening of children aged 1-9 years is proposed as a more sensitive and specific strategy.
The clinical efficacy of universal screening for FH in children requires further validation.