Related Experiment Video
Updated: May 29, 2026

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
Published on: June 2, 2015
Platelet activity indices in patients with deep vein thrombosis
Nurdan Cay1, Ali Ipek, Mehmet Gumus
1Department of Radiology, Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey. nurdancay@yahoo.com
Background:
Extensive research has been performed regarding the association between platelet activity indices and various cardiovascular disorders. Less clear data, however, are present between these indices and deep vein thrombosis (DVT).
Aim:
The aim of this study was to investigate the association between platelet activity indices and DVT in a relatively large population.
Methods:
Mean platelet volume (MPV), mean platelet mass (MPM), and mean platelet component (MPC) were measured by an autoanalyzer in a total of 203 patients with DVT and the results were compared with 210 age- and sex-matched controls without DVT.
Results:
There were significant differences between the study and control groups in MPV (8.6 ± 1.3 fL vs 7.9 ± 0.5 fL [95% CI -0.82 to -0.44], P < .001, respectively), MPM (2.2 ± 0.3 pg vs 2.0 ± 0.1 pg [95% CI -0.20 to -0.11], P < .001, respectively), and MPC (24.9 ± 3.2 g/dL vs 26.3 ± 1.6 g/dL [95% CI 0.91 to 1.89], P < .001, respectively). These 3 platelet activity indices were also found to be significant predictors of the presence of DVT (all Ps < .001).
Conclusion:
In patients with DVT, the presence of DVT was closely associated with increased platelet activation. The MPV, MPM, and MPC may identify patients requiring aggressive antiplatelet treatment.
Related Concept Videos
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
Venous Thrombosis III: Interprofessional Care
Venous Thrombosis IV: Nursing Management
Venous Thrombosis I: Introduction
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Anticoagulant Drugs: Low-Molecular-Weight Heparins
