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Clonal evolution through loss of chromosomes and subsequent polyploidization in chondrosarcoma
Linda Olsson1, Kajsa Paulsson, Judith V M G Bovée
1Department of Clinical Genetics, University and Regional Laboratories, Skåne University Hospital, Lund University, Lund, Sweden.
Plos One
|September 28, 2011
Summary
Chondrosarcoma tumors frequently exhibit chromosome loss, leading to near-haploid cells that may undergo polyploidization. This study confirms chromosome number alterations are common in chondrosarcoma development.
Area of Science:
- Oncology
- Cytogenetics
- Cancer Genomics
Background:
- Near-haploid chromosome numbers are rare in tumors but observed in chondrosarcoma.
- Previous literature suggests chromosome loss is a feature of chondrosarcoma karyotypes.
Purpose of the Study:
- To investigate the prevalence and patterns of chromosome number alterations in chondrosarcoma.
- To determine if hyperhaploid-hypodiploid cells are a common origin in chondrosarcoma and if they undergo polyploidization.
Main Methods:
- Literature survey of published chondrosarcoma karyotypes.
- Single nucleotide polymorphism (SNP) array analysis of 16 chondrosarcoma samples.
Main Results:
- Literature survey confirmed chromosome loss and polyploidization in chondrosarcoma.
- SNP array analysis revealed hyperhaploid-hypodiploid origins in most chondrosarcomas, with or without polyploidization.
- Common autosomal loss of heterozygosity (excluding chromosomes 5, 7, 19, 20, 21) resulted from chromosome loss and uniparental disomy.
Conclusions:
- Chromosome loss and subsequent polyploidization are common events in chondrosarcoma development across subtypes.
- Complex karyotypes in chondrosarcoma arise from chromosome loss, polyploidization, and additional genetic alterations.
- While binucleated cells are found in chondrosarcoma, they do not appear to be the primary drivers of chromosome loss and polyploidization events.
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